Is absolutely recommended to walk from one place to another since all the locations are in the Vatican City.
To visit the sites mentioned it takes about 2 or 3 hours, depends on the time you decide to stop in the places.
This route allows you to learn more about of St Peter's Basilica, one of the four papal basilicas in Rome, and St Peter's Square.
The itinerary starts from the subway station "Ottaviano" (Line A). Walking a few meters you get to the heart of the great St Peter's Square. The square is dedicated to St Peter and is a great example of Baroque architecture. The square has an oval shape and in the center is located the Vatican obelisk. The square is also surrounded by a large colonnade architrave and every Sunday is filled with the faithful who come from all over the world to attend the Mass of the Pope. After taking some pictures of the square we advise you to continue the journey with a visit to the St Peter's Basilica built over St Peter's tomb. The Basilica can accommodate 20,000 people, and is one of the largest religious buildings in the world. Its interior, characterized by a vast mosaic, are the treasure chest for some of the most famous artworks in the world, such as the canopy of Bernini and the statue of the Pietà by Michelangelo.
From here we recommend the following itineraries:
Vatican City Itinerary 2
Fascism in North of Rome
Historic Center Itinerary 4
Shopping in Center Itinerary 2